Pharmatek: Pharmaceutical Chemistry Development specializes in compound selection, analytical development and formulation development. Based in San Diego, Pharmatek is known for it's own Hot Rod Chemistry and Formulation Screening Kit.

Compound Evaluation
Analytical Methods Development
Preformulation Testing
Formulation Development
GMP Manufacturing
Stability Testing/Storage
Cytotoxic and High-Potent Development
Total Quality Excellence
Pharmatek, 1999-2009: 10 Years of Great Chemistry
Formulation Development
Each formulation is unique, just as each drug candidate is unique. At Pharmatek, formulation projects start with a strategic formulation plan. The formulation strategy is the result of a thorough analysis of the preformulation data report, the intended manufacturing process, any patient compliance issues and the strategic goals of the company.

At Pharmatek, our team of formulation scientists has a comprehensive understanding of both solid oral drug product development & injectable drug product development. We understand that certain candidates present specific challenges such as low bioavailability, poor solubility and/or permeability and poor physical stability. Formulation development can be helpful in overcoming many of these issues. Our priority is to always provide a safe and robust formulation to meet our clients' early-stage development goals.

Execution of the formulation strategy utilizes a logical, data driven approach:

  • Pre-formulation solubility and stability evaluations
  • Comprehensive excipient screening
  • Prototype development
  • Formulation optimization and finalization
  • Supporting documentation and data package

To learn more about our first-in-man strategies please click here.

Preclinical Formulation Development Capabilities:

  • Parenteral formulations: toxicology formulation development & stability studies with GLP support, placebo development, liquid in a vial, powder in a vial for reconstitution, lyophilized powder for reconstitution
  • Oral formulations: solutions, suspensions, emulsions, capsules, tablets, coated capsules or tablets (for non-rodent species)

  • To learn more about our Solutions for Insoluble Compounds please click here.

Clinical Formulation Development Capabilities:

  • Parenteral formulations: clinical formulation development & stability studies, container/closure & delivery component compatibility studies, placebo development, liquid in a vial, powder for reconstitution, lyophilized powder for reconstitution
  • Oral formulations: powder in a bottle for reconstitution, solutions (aqueous or organic), suspensions, emulsions, SEDDS, taste-masked solutions, neat API in a capsule, liquid filled capsules, semi-solid filled hard shell capsules, formulated capsules, formulated tablets
    • Tablet and capsule formulation capabilities: direct blending, dry granulation/roller compaction, wet granulation (bottom or top driven, high or low shear, top-spray fluid bed), melt granulation, multiparticulates, sustained release matrix tablets, amorphous dispersions (spray drying), orally disintegrating tablets
    • Tablet, capsule, or multiparticulate coating (pan coating or Wurster fluid bed coating): film/color coating, taste masking, moisture protective coating, enteric/targeted delivery coating, extended/sustained release coating
    • Injectable dosage forms: intravenous, intramuscular, intraperitoneal, subcutaneous, cyclodextrin, lyophilization
  • Click here to learn more about Pharmatek's Injectable Development Capabilities.

Note: All formulation development techniques can be applied to both non-potent and highly-potent/cytotoxic compounds

The Pharmatek Difference
Formulation development is often seen as a black box. At Pharmatek, it's a science. Our logical, data-driven approach to formulation development gives your compound the best chance at success and provides our clients the most efficient, straightforward process for manufacturing their compound.