Hot Rod Chemistry® (PDF)
Every year hundreds of drug candidates are abandoned due to poor solubility. Formulation technology becomes a key enabler for ensuring continued development. Pharmatek Laboratories' Hot Rod Chemistry® (HRC) is a formulation screening kit designed to solubilize drug candidate compounds and prepare them for testing in animal models.
Safe - Effective - Fast
Each HRC® kit contains eight non-toxic, orally available formulations that increase the solubility, bioavailability and stability of oral drug candidates. Each formulation has been created using functional excipients that are GRAS and can be found in FDA approved therapeutics.
The formulations have been tested with a number of small molecules regarded as highly insoluble including taxol, griseofulvin and probucol. 95% of compounds tested have proven to be soluble in at least one HRC® formulation. Each formulation was created to be compatible with molecules containing different functional groups.
HRC® can be used as part of any drug discovery program and is currently used in over 200 pharmaceutical, biotechnology and academic laboratories around the world. By quickly and inexpensively testing compounds using the kit, HRC® alleviates the bottleneck between in vitro hits and in vivo results, drastically improving its chances of becoming a viable drug candidate. Additionally, compounds previously shelved can now be reevaluated using the kit.
To order a Hot Rod Chemistry® kit, click here to download the order form & fax to
HRC began as a rational approach to formulating compounds, one that took the black magic out of formulation chemistry. HRC has become a vehicle for streamlining the drug discovery process, simultaneously lowering costs and increasing the number of viable drug candidates in the drug development pipeline.
All of these formulations are designed for oral dosing. The formulations that are liquid at room temperature can be dosed to your animals via syringe (oral gavage). Larger animals may be easily dosed with hard gelatin capsules from Capsugel. Capsugel has a Licap™ capsule that seals, thus allowing dosing of liquid or semi-solid formulations in hard gelatin capsules.
If your compound is designed for intravenous dosing, please contact Pharmatek for information regarding our HRC Rapid Formulation Development Service.
To order a Hot Rod Chemistry® kit, download the order form and fax to 858-578-0403.
If you have questions about Hot Rod Chemistry®, please contact Customer Support at:
858-805-6383 or firstname.lastname@example.org.